Do Inactivation Mechanisms Rather than Adaptation Hold the Key to Understanding Ryanodine Receptor Channel Gating?
نویسندگان
چکیده
The use of flash photolysis of caged Ca 2 1 to rapidly elevate [Ca 2 1 ] at the cytosolic face of a cardiac ryanodine receptor (RyR) channel reconstituted into a bilayer gives rise to a rapid increase in open probability (Po; Györke and Fill, 1993). This is followed by a decline in Po, which occurs much more slowly ( t 5 1.3 s). After the decline in Po, the channels can be reactivated by a second Ca 2 1
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ورودعنوان ژورنال:
- The Journal of General Physiology
دوره 116 شماره
صفحات -
تاریخ انتشار 2000